EPA Method 533: PFAS in Drinking Water
Certified PFAS standards, isotopically labeled analogues, anion exchange SPE cartridges, and consumables — curated for compliant Method 533 LC-MS/MS analysis.
Compliance Requirements for Method 533
EPA Method 533 is an approved analytical method for determining select per- and polyfluoroalkyl substances (PFAS) in drinking water. It uses isotope dilution, anion exchange solid phase extraction (SPE), and liquid chromatography/tandem mass spectrometry (LC-MS/MS) to achieve detection at low ng/L (ppt) levels.
Critical Note: Method 533 expands PFAS monitoring capabilities beyond EPA Method 537.1 by including short-chain PFAS and replacement compounds (such as HFPO-DA / GenX) that cannot be reliably measured with earlier methods. Laboratories must use isotopically labeled analogues for isotope dilution quantitation and anion exchange SPE cartridges for extraction.
We have curated the standards, SPE products, and consumables below specifically to support compliant EPA Method 533 workflows.